 This review assesses the relationship between the characteristics of serious games, SG's, and their impact on clinical outcomes in motor impairment rehabilitation for patients with stroke, multiple sclerosis, or cerebral palsy. The study found that custom-made casual games played in single-player mode using non-immersive virtual reality attain the best results in terms of positive clinical outcomes. Additionally, custom-made games tend to give better clinical results than commercial off-the-shelf games, although the latter are perceived as more motivating and engaging. This article was authored by Caterina Vieira, Carla Ferreira de Silva Pius Vieira, Joao Novais, and others.