 The prevalence of mutated strains of SARS-CoV-2 has created a need for a cost-effective, rapid and reliable method of detecting virus levels in public spaces. Researchers are exploring new strategies to target, bind, and confirm the presence of viruses before they spread. One approach involves synthetic DNA constructs designed to specifically recognize SARS-CoV-2 antigens. These constructs can then be used to create complementary DNA, cDNA, or protein DNA complexes, which can be detected using small molecules, cDNA, or protein DNA complexes. Nanomaterials with unique electronic properties, like graphene, may also be used to develop a device with extremely low detection limits, septimolar or atomolar. To ensure accuracy, surface modifications must be made to the device to provide high sensitivity while maintaining rapid signaling capabilities. This article was authored by Narendra Chandrasekhar, Ramachandran Balaji, Ramaswamy Sundeep Parila, and others.