 This research examines the effects of pregnancy on kidney function and how it differs from non-pregnant states. It also considers the effects of chronic hypertension on kidney function during pregnancy. The research uses computer modeling to simulate the effects of various factors on kidney function, including changes in proximal tubule length, NHE3 activity, enosci activity, K plus secretory channel expression, and H plus K plus ADPase activity. The results suggest that the enosci and H plus K plus ADPase transporters are essential for sufficient Na plus and K plus reabsorption during pregnancy. Additionally, the research suggests that in hypertensive conditions, the shift in Na plus transport from the proximal tubules to the distal tubules is similar to that seen in a non-pregnant state. This article was authored by Melissa M. Stott, Crystal A. West and Anita T. Layton.