 Hi everyone, my name is Tao Yang, and the corresponding author of a recent paper entitled A Dominant Mutation in the Stereocilia Ecstasygene TBC1D24 is the proper cause of non-syndromic hair impairment. In this study, we performed a linkage analysis and a whole-exam sequencing in a large Chinese family segregated with old somal dominant non-syndromic deafness. As you will see in our paper, we identified a heterozygous miscellaneous mutation in TBC1D24 as the proper cause of deafness in this family. Recessive mutations in TBC1D24 have been recently reported to be associated with both syndromic and non-syndromic deafness. Our study, however, is among the first to show that dominant mutations in TBC1D24 may lead to non-syndromic deafness with later onset and milder degree in severity. By immunostaining of the mouse cochlear, we also show that TBC1D24 is expressed at the stereocilia of the hair cells as well as the spiroganic neurons. This funding may provide new insights into the specific function of TBC1D24 in the inner year. Well, I hope you enjoy reading our paper. Please send me email if you have any questions and comments.