 This study examined the effects of polygenic risk scores, PRS, genetic variants associated with colorectal cancer, CRC, and family history, FH, on CRC risk. Non-carriers had a lower risk than carriers, while those with a high PRS had a higher risk. Carriers with a low PRS had a similar risk to non-carriers, while carriers with a high PRS had a much higher risk. Those with a suspicious FH also had a higher risk, while those with no FH had a lower risk. The authors concluded that PRS, carrier status, and FH all play important roles in determining CRC risk.