 This research has developed a novel nanoplatform consisting of mulberry leaf-derived nanoparticles loaded with resveratrol nanocrystals and fluorinated pleuronic polymer. The nanoplatform can be used to treat ulcerative colitis through its ability to improve mucus penetration, reduce inflammation, and restore integrity of the intestinal wall. This article was authored by Wenjin Yang, Yang Ma, Hading Su, and others.