 Synthetic biology has the potential to revolutionise the way in which diseases are diagnosed and treated. By combining engineering principles with biological systems, it can create sensors, control circuits and actuators within the body to provide more accurate and precise diagnosis. This technology also allows for the development of customisable, programmable and autonomous diagnostic devices that can be tailored to each individual patient's needs. Synthetic biology is poised to make a significant impact on the future of medicine by providing faster, more accurate diagnoses and treatments, as well as helping to address global health issues. This article was authored by Alexis Corbett, Eric Renaud and Frank Molina.