 This study assesses the challenges faced by caregivers of individuals with mental disorders in Greece, identifying demographic factors that influence their well-being. Caregivers, especially women and younger individuals, experience high levels of mental health challenges. Marital status, educational level, and employment status also significantly impact caregivers' well-being. Depression is the most significant factor negatively correlating with the mental component of quality of life. The findings emphasize the need for targeted social and financial support, as well as strategic treatment programs that consider caregiver well-being, particularly in the context of the COVID-19 pandemic. This article was authored by Vasiliki Oikonamu, Evgenia Kintoni, Konstantinos Hakiopoulos, and others.