 The study evaluated the efficacy and safety of pulsed-eye laser, PDL, for discord lupus erythematosus, DLE, in a double-blinded, randomized, controlled fashion. The results showed that PDL treatment significantly decreased erythema index, EI, texture index, TI, and improved physician global assessment, PGA, scores compared to the control. Though there was improvement of modified cutaneous lupus erythematosus disease area and severity index MCLASI in the laser group, the significance difference was not observed. Real-time polymerase chain reaction showed a reduction in CXCL-9, 10, IFN, Illinois, 1-beta, TNF, and TGF. Additionally, post-treatment DLE lesions demonstrated decreased CD3, CD4, CD8, and CXCR3 positive cells. The study concluded that improvements of DLE can be achieved with PDL. This article was offered by Pawini Rognimita, Nuka Rintekakering, Ratchaforn Panchapratip, and others. We are article.tv, links in the description below.