 Shear-sensitive liposome-based drug delivery systems have been developed to overcome the challenges of delivering drugs to specific locations without damaging healthy tissue. Shear stress has been used to model the complexities of the human body, such as constricted blood vessels, which can lead to increased shear stress and cardiovascular disease. Liposomes are a popular choice for drug delivery because they are soft and deformable, highly biocompatible, and sensitive to shear stress. This review discusses how shear stress affects liposomal structures, flow regimes, and rheological properties, as well as its potential use in drug delivery applications. This article was authored by Sulking Keras and Erkan Senses.