 Silver nanoparticles have antiviral activity against IV-1 at non-cytotoxic concentrations, and they exert this activity by binding to GP120 and inhibiting viral entry and post-entry stages of the life cycle, making them a broad-spectrum agent that could be used preventively against circulating IV-1 strains. This article was authored by Rodry Gespadilla-Christina, Ixtapantarant Liliana, Ayala Nunez Nildavee, and others.