 This qualitative study explored the experiences of people who use drugs, PWUS, regarding virtual overdose monitoring services, VOMS, which provide immediate support during an overdose event. PWUS reported feeling optimistic about the potential of VOMS as a suitable harm reduction intervention, but also expressed concern about certain aspects of the service, including reliability of cell phone reception, emergency response times, lack of mental health supports, and limited public awareness. These findings suggest that further research is necessary to understand how best to optimize VOMS to ensure its successful implementation and uptake among PWUS. This article was authored by Tyler Marshall, Dylan Vist, Stephanie Jones, and others.