 This study found that the prevalence of behavioral intentions of COVID-19 vaccination was very low in the Hong Kong general population, especially among younger people, females, and single people. Factors such as trust slash satisfaction towards the government, exposure to positive social media information about COVID-19 vaccines, descriptive norms, perceived impact on the pandemic, perceived duration of protectiveness, and life satisfaction were positively associated with the intention of taking up COVID-19 vaccination. Health promotion is warranted to enhance the intention of taking up COVID-19 vaccination. This article was authored by Yen Chiu Yu, Joseph Tief Lao, Mason M. C. Lao, and others.