 The pervasive problem of irreproducibility of pre-clinical research poses a significant threat to the translation of clinical trials generated by CTSA hubs. Stakeholders have proposed solutions to address this issue, but their efforts have been largely unsuccessful due to a lack of focus on the processes of research rather than the products, as well as the absence of consideration of the incentives that drive the research enterprise. To address this issue, CTSA hubs should leverage the principles of team science and the science of team science, SOTS, to develop strategies that promote reproducible research practices from the beginning of the project through its completion. These strategies should include building team-based best practices and identifying observable behaviors that indicate a culture of reproducible research. This article was authored by Betsy Rowland, Elizabeth S. Burnside, Corinne I. Voiles, and others.