 The relapse prevention, RP, model is a widely used addictions theory and treatment approach that has been in use for over three decades. This paper provides an update on RP, focusing on developments from the past decade, 2000 to 2010. Major treatment outcome studies and meta-analyses are summarized, along with relevant empirical findings related to the RP models tenets. Notable advances in RP during this time include the introduction of a reformulated cognitive behavioral model of relapse, the application of advanced statistical methods to model relapse in large randomized trials, and the development of mindfulness-based relapse prevention. The paper also reviews emerging literature on genetic correlates of relapse following pharmacological and behavioral treatments. Despite being subsumed within other treatment modalities, RP remains an influential cognitive behavioral framework that can inform both theoretical and clinical approaches to understanding and facilitating behavior change. This article was authored by George William H, Whitkey Witt's Katie, Hendershott Christian S, and others. We are article.tv, links in the description below.