 The study found that violet light exposure effectively suppressed myopia progression in experimental chick and mice models of myopia, that the inhibitory effects were reduced in retina-specific opsin-5, opn-5, knockout, kao, mice. Furthermore, VL exposure upregulated early growth response 1, egg-1, expression in the corioretinal tissues of chicks, and this effect was also observed in mouse retinal 661W cells following VL exposure. However, the expression of EGR-1 and role of opn-5 in mice following VL exposure remain unclear. The study suggests that opn-5 mediates VL-induced EGR-1 upregulation in mice, and these molecular targets could be considered for the prevention and treatment of myopia. This article was authored by Heonuk Jong, Diokoli, Xiaoyang Jiang, and others.