 Confidence in network meta-analysis, CINEMA, is a new methodology for evaluating the credibility of results from network meta-analyses. It takes into account six key factors within study bias, reporting bias, indirectness, imprecision, heterogeneity, and incoherence to determine whether the results from a network meta-analysis should be trusted or not. This methodology is particularly useful when multiple interventions are being compared as it allows for more accurate assessment of the reliability of the results. This article was authored by Adriene Nicolacopola, Julian P. T. Higgins, Theodoros Papakonstantinou, and others.