 This study investigated the use of a novel biocompatible material, poly-D-l-lactic acid, slash-arginal-glycelespartic acid, RGD peptide, modification of poly-lactic acid, co-dash, glycolic acid, alt-l-icene, PRGD-slash-PD-LLA, as a nerve conduit to reduce neuroma formation following amputation. The PRGD-slash-PD-LLA-capped group showed improved recovery with less autonomy scores and fewer inflammatory infiltrates than the uncapped group. Additionally, the PRGD-slash-PD-LLA-capped group had better myelin sheath regrowth and gene expression levels compared to the uncapped group. These results suggest that PRGD-slash-PD-LLA may be a viable option for reducing neuroma formation following amputation. This article was authored by Jilin Yi, Nan Jian, Bindan Lee, and others.