 The study found that exosomes from mesenchymal stem cells, master of science, have a beneficial effect on acute lung injury, ALI, but the effective components need further investigation. The study used an LPS-induced ALI mice model and in vitro inflammatory model to evaluate cell proliferation, apoptosis, and lung injury. The results showed that mere 132-3P negatively regulated TIF6 by direct binding and potentiated proliferation and suppressed apoptosis of LPS-induced MLE-12 cells at least partly dependent on targeting TIF6. Treatment of exosomes alleviated the LPS-induced ALI in mice and LPS-induced inflammatory response in MLE-12 cells, an overexpression of mere 132-3P promoted the protective effect of exosomes in LPS-induced MLE-12 cells injury and LPS-induced ALI. The study suggested that mere 132-3P mediated the protective effect of MSC-derived exosomes on LPS-induced ALI via targeting TIF6 and inactivating PI-3K act signalling. This article was authored by Chen Huoliu, Chen Li, Liang Cao, and others. We are article.tv, links in the description below.