 Knowledge mobilization, kilometer, is a process that seeks to increase the impact of research findings in policy and practice. Systems thinking is a methodology that can be used to facilitate kilometer efforts. This paper presents a systemic approach to kilometer called the Systems Thinking Guide for Knowledge Mobilization, SDGKM. It was developed through a five-step process involving an inductive thematic synthesis of existing literature, reflexive deliberations, development of a set of questions, trialling the questions at workshops, and revision based on user feedback. The SDGKM consists of 13 questions and 18 sub-questions that can be used to help researchers frame their kilometer strategies from a systems perspective. Future applications of the SDGKM will be tested and reported upon. This article was authored by Michelle J. Irving, Melanie Peskard, Eloise Howes, and others.