 The study aimed to identify short-term learning and long-term practice effects in six smartphone-based tests for cognition, dexterity, and mobility in people with multiple sclerosis. The results showed strong practice effects for cognitive and dexterity functions, but not for mobility. These findings suggest that smartphone-based tests are promising for monitoring the disease trajectories of MS and other chronic neurological diseases, but long-term practice effects have to be accounted for in cognitive and dexterity domains. This article was authored by Tim Wolfel, Sylvan Pless, Andrea Wienseers, and others.