 Cocaine is the most used psychostimulant in Europe. Our estimation is that about 2 million young adults have used it last year. A small number of those using cocaine will develop some problems. Cocaine is a powerful stimulant, its effects include increased energy, feelings of intense pleasure, but also anxiety and paranoia. The drug does this by disrupting the normal signalling pathways in the body. For example, cocaine causes a buildup of dopamine in the brain and this is responsible for the feelings of intense pleasure. But with repeated use, users find that they have to take more of the drug to get the same effects because cocaine can dampen the ability to feel pleasure. For heroin, during the last decades, there has been substitution medication to help users like methadone, buprenorphine and other drugs, but this is not the case for cocaine users. Nevertheless, many medications are being studied for helping those using cocaine. We are trying to find out what kind of medications. Medicines that somehow activate GABA. Medicines that will change dopamine. Medicines that admit that they can work with substitution therapy, although this is not very clear. There has been a very wide number of medications that have been used over time, and I have also used them. There has been a fact that I wanted to mention that there is no substance that is approved for treatment of cocaine. Therefore, we are committed to the prehistory of cocaine treatment. While research on pharmacological intervention is ongoing, this standard treatment for cocaine users is a combination of cognitive and behavioral interventions.