 The metabolic syndrome is a combination of cardiovascular and metabolic conditions including high blood pressure, insulin resistance, dyslipidemia, and excessive belly fat. Obesity is linked to a chronic inflammatory response which leads to the production of abnormal adipochemes, the activation of pro-inflammatory signaling pathways, and the induction of various biomarkers of inflammation. This inflammation is caused by macrophage and lymphocyte infiltration in adipose tissue which contributes to the development of metabolic disorders. A deponectin can either directly affect macrophages or prime human monocytes into anti-inflammatory M2 macrophages. In addition, the chronic inflammation in adipose tissue is regulated by a series of transcription factors, primarily paraxies and proliferator-activated receptors, PPARs, and CCAAT-enhancer binding protein, CEBP, which together control the expression of hundreds of proteins involved in lipid metabolism and secretion from adipocytes. This article was authored by Eduardo Fuentes, Francisco Fuentes, Gemma Villajor, and others. We are article.tv, links in the description below.