 This study proposes a novel approach to treating drug-resistant bacteria using a non-antibiotic method called furoptosis. The researchers developed two single-atom catalysts, sacs, consisting of ruthenium and iridium which are capable of generating reactive oxygen species when exposed to light, or hydrogen peroxide. These sacs were then used to treat various types of bacteria including MRSA, gram-positive and negative bacteria, and biofilms. The results showed that these sacs were highly effective at killing the bacteria and also had good biocompatibility and therapeutic potential. This study suggests that this non-antibiotic approach could be used to treat drug-resistant bacteria and provide a promising alternative to traditional antibiotics. This article was offered by Baohong Sun, Xinyu Wang, Ziqiu Yi, and others.