 This study investigates the effects of adding synth-sized iron oxide, magnetite, nanoparticles, MNPs, topolelactic, co-oaglycolic acid, PLGA, gelatin scaffolds. The MNPs were characterized using various techniques such as transmission electron microscopy, Fourier transform infrared spectroscopy, x-ray diffraction spectroscopy, and vibrating sample magnetometer analysis. The results showed that the MNPs did not have any significant effect on the morphology of the pores or the pore-sized distribution. However, they did increase the mechanical strength of the constructs and reduce their absorption capacity and biodegradation rate. Additionally, the stability of the MNPs and lack of iron release was the main reason for the success of this investigation. Finally, the evolution of rat bone marrow mesenchymal stem cell performance on the hybrid structure under a static magnetic field, indicated the potential of superparamagnetic constructs for future preclinical and clinical studies in the field of neural regeneration. This article was authored by Farnas Gorbani, Ali Zamanian, Alireza Shams, and others. We are article.tv, links in the description below.