 Lignin, a natural polymer found in plant cell walls, has become increasingly popular in the development of novel biomaterials for drug delivery applications. This review provides an overview of the design and fabrication strategies of Lignin-based biomaterials such as hydrogels, cryogels, electrospun scaffolds, and three-dimensional 3D printed structures, and discusses their potential use in drug delivery applications. The review also highlights the advantages and challenges associated with each biomaterial fabrication strategy and outlines the prospects and future directions of Lignin-based biomaterials in the pharmaceutical field. This article was authored by Turta Mohamed Abdullah, Gullmeyer Ilias Aglu, and Adnan Memic.