 Shift bases and their complexes are versatile compounds synthesized from the condensation of an amino compound with carbonyl compounds and widely used for industrial purposes. They exhibit a broad range of biological activities including antifungal, antibacterial, antimalarial, antiproliferative, anti-inflammatory, antiviral, and antipyretic properties. Many shift base complexes show excellent catalytic activity in various reactions and in the presence of moisture. These complexes are often used in homogeneous and heterogeneous catalysis due to their high thermal and moisture stability. The activity of these complexes is typically enhanced through complexation which allows researchers to better understand the properties of both ligands and metals. The coordination behavior of certain metals with shift bases has led to the development of highly active compounds which are being studied for potential use in chemotherapy. This article was authored by Ahmed M. Aboudif and Ibrahim M. Mohamed.