 Nanoparticle synthesis has become increasingly important in recent years due to their wide range of applications. Green synthetic methods have emerged as a viable alternative to traditional physical and chemical methods, as they are safer and more environmentally friendly. Additionally, these methods have been found to be effective in biomedical applications such as imaging, drug delivery, biosensors, and gene delivery. Furthermore, ZNONPs have been shown to possess antimicrobial activity, making them useful in combating multi-drug-resistant pathogens. This article was authored by V. N. Kalpana and V. Davy Rajaswary.