 Protonic ceramic electrochemical cells, sex, have been extensively researched as a potential technology for generating electricity, storing energy, and performing sustainable chemical synthesis. In recent years, there have been significant advancements in electrolyte and electrode materials used in sex, but the development of catalysts for synthesizing chemicals in sex has received less attention. This review provides an overview of the current state of knowledge regarding the use of sex for synthesizing various chemicals, including ammonia, carbon monoxide, methane, light olefins, and aromatics. It also discusses factors that affect the conversion rate, selectivity, product yield, and energy efficiency of sex. Finally, it offers strategies for addressing the challenges associated with using sex for chemical synthesis, such as designing electrodes and optimizing material selection. This article was authored by Fan Lu, Dong Ding, and Chuancheng Duong.