 Despite ongoing efforts to develop effective vaccines against human cytomegalovius, HCMV, no successful candidates have been found in either virus modification or individual antigen approaches. Recent research has shown that a pentameric complex is necessary for generating potent neutralizing antibodies, which should be considered in vaccine design based on improved understanding of natural HCMV immunity. This article was offered by Linxia, Ruopansu, Jichyongen and others.