 Plants are a vital source of new drugs with medicinal importance in drug development and many of the drugs sold today are simple synthetic modifications or copies of naturally obtained substances. Secondary metabolites have commercial importance as drugs, flavor and fragrances, dye and pigments, pesticides and food additives. Plant cell and tissue culture technologies can be established routinely under sterile conditions from explants for multiplication and extraction of secondary metabolites. The present review focuses on the frithotherapeutic application and recent advancement for the production of important plant pharmaceuticals. This article was authored by M. D. Sarfaraj Hussain, Shiba Fareed, Saba Ansari and others.