 This study suggests that the presence of higher levels of CD4 plus T lymphocytes and a lower CD4 plus CD8 plus ratio are associated with better tumor differentiation, an earlier clinical pathological stage, lower key 67 expression, shallower tumor infiltration, a smaller number of lymph node metastases, a lower CEA content, and a lower likelihood of nerve or vascular infiltration. Additionally, after effective surgical treatment, the CD4 plus T lymphocyte content and CD4 plus CD8 plus ratio increase significantly, while the CD8 plus T lymphocyte content decreases significantly. The authors suggest that this could be used as a potential biomarker for assessing the prognosis of colorectal cancer. This article was authored by Chaofeng Yuan, Jianen Huang, Hai Tao Li, and others.