 We face a global challenge. The way we produce and consume food today is unsustainable. But we can still change this. The world needs a holistic and sustainable approach to transform our agri-food systems for better production, better nutrition, a better environment and a better life, leaving no one behind. And livestock plays an important role in achieving these aspirations. By making significant and positive changes to the livestock sector, we can ensure its long-term viability, ecological balance and social responsibility. Sustainable livestock transformation looks at practices that can improve food security and nutrition and livelihoods of those involved in the sector. Promote animal health and welfare, minimize negative environmental impacts and reduce greenhouse gas emissions. The aim is to create an efficient, inclusive, resilient and environmentally conscious livestock sector that meets the needs of populations today and conserves resources for those who will come tomorrow. Effective and sustainable livestock transformation requires country and context-specific approaches that recognize the diversity of livestock systems across the world. Tailoring interventions to national and local needs, resources and knowledge is crucial to integrating sustainable practices within existing systems. To make a sustainable livestock transformation possible, we must build global, balanced and evidence-based narratives on sustainable livestock. Strengthen pathways to expand good practices that promote sustainability. Support policy development and responsible investment that align with sustainability goals. Integrate animal production, health and welfare following the One Health approach to foster the development of holistic and sustainable systems and accelerate actions, innovations and partnerships that drive meaningful change more efficiently. Now is the time to engage in dialogues on innovation and pathways for more nutritious, safe and accessible animal source foods with a reduced environmental footprint. The Food and Agriculture Organization of the United Nations serves as a neutral forum, bringing together stakeholders from across the world interested in building vibrant, resilient and diversified livestock systems. Together we can unlock the full potential of livestock systems for a sustainable and food secure world for all.