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Published on Jan 14, 2016
DROSHA cuts microRNA precursors to generate functional microRNAs that are critical for many biological processes in both animals and plants. The structure of DROSHA solved by scientists led by Narry Kim in Korea (link) and its striking structural similarity with DICER, another enzyme responsible for the subsequent step of microRNA process, provide valuable mechanistic insights into microRNA biogenesis. Check out the paper at: http://www.cell.com/cell/abstract/S00....
S. Chul Kwon, Tuan Anh Nguyen, Yeon-Gil Choi, Myung Hyun Jo, Sungchul Hohng, V. Narry Kim, and Jae-Sung Woo (2014). Structure of Human DROSHA. Cell 164.