 Abstract Alzheimer's disease, AD, is a common neurological disorder characterized by dementia, memory loss and reduced cognitive ability. The accumulation of amyloid beta, A, plaque deposits, production of reactive oxygen species, and mitochondrial dysfunction are all indicators of AD. Research has focused on the potential of natural phyto-bioactive compounds, such as resveratrol, RES, to protect against neurodegeneration. Studies have demonstrated the neuroprotective effects of RES which can be enhanced by encapsulating it into various nanoparticle forms. These nanoparticles can then be used to increase the bioavailability and stability of residential at the target site in the brain, thus improving the effectiveness of AD treatment. This article was authored by Cyrus Jalalai, Meir Kehani, Bahamadri Zid al-Ami, and others.