 Abstract osteoarthritis, OA, is a degenerative joint disease characterized by cartilage loss and bone erosion. The disease is often accompanied by inflammation, which can further aggravate the condition. In this study, researchers have developed a new type of scaffold material called Zincobalt Organic Framework, ZN-slash-CoMOF, Functionalized Biosuramic Scaffolds, MOFTCP. These scaffolds contain both catalytic active sites and degradation products, which allow them to actively scavenge reactive oxygen species, ROS, and reduce inflammation. Additionally, they can induce both osteogenesis and chondrogenesis, allowing for faster healing of damaged cartilage and bone. Finally, in vivo tests showed that MOFTCP scaffolds were able to significantly improve the healing of severe osteochondral defects caused by OA. This article was authored by Chaoqin Xu, Chen Qin, Lei Chen, and others. We are article.tv, links in the description below.