 Magnesium-based metals have been shown to possess desirable mechanical and osteo-inductive properties, making them promising candidates for orthopedic implants. However, there remain several challenges associated with their use in clinical settings due to their limited strength and poor biocompatibility. In this review, we discussed the current state of research into MG-based orthopedic implants, including their potential advantages over conventional materials, as well as the challenges they face before being used in clinics. We also highlight some of the innovations that have been developed to overcome these challenges, such as the incorporation of MG-based alloys into hybrid systems. Overall, the progress made in the field of MG-based orthopedic implants has provided a solid foundation for further advancements in this area. This article was authored by Jolly Wang, Jin Kuansu, Chelsea Hopkins, and others.