 This study examined the relationship between serum interleukin 1 receptor antagonist, IL-1RA, levels and major depressive disorder, MDD. No significant difference was found between the levels of IL-1RA in MDD patients compared to healthy control subjects. Additionally, there was no correlation between the severity of depression and serum IL-1RA levels. These results suggest that IL-1RA may not be a reliable biomarker for risk assessment of depression. This article was authored by Zabouin Nahar, Sharon Tisney Monisha, MMA Shallahuddin Cusar, and others.