 The study aimed to evaluate the effectiveness of a short, wordless, animated global health communication video in improving COVID-19 prevention knowledge and increasing behavioral intent toward COVID-19 prevention. The video was rapidly distributed through social media channels to an international audience and reached 1.2 million views within the first 10 days of its release. The results showed that the video intervention was effective at boosting knowledge of COVID-19 prevention, but only captured a measurable change in behavioral intent toward one of the five preventive behaviors examined in the study. The global reach and high voluntary engagement of trial participants highlight several innovative features that could inform the design and dissemination of public health messages during health crises. This article was authored by Alain van de Meijer, Maya Adam, Merlin Gruel, and others.