 TRP channels are a diverse group of ion channels that play a critical role in sensory perception, cellular communication, and homeostasis. They are located primarily on the cell membrane and respond to a variety of external stimuli, such as temperature, mechanical pressure, and chemical compounds. These channels have been implicated in the development of many diseases, making them promising targets for drug discovery. This article was authored by Niao Zhong, Yiming Ma, Xiang Li Yi, and others.