 Chow2 at DOEX at ZIF67 is a novel nanomedicine designed to deliver oxygen and hydrogen peroxide to cancer cells for enhanced chemo-slash-chemodynamic therapy. It works by breaking down in the acidic environment of tumors, releasing the fetin-like catalyst CO2-plus and the chemotherapy drug doxorubicin, DOEX, which are then able to penetrate deeper into the tumor. Once inside the tumor, the CO2-plus reacts with water to create hydrogen peroxide, which can then be used to oxidize the CO2-plus to form more toxic hydroxyl radicals. This combination of treatments has been shown to be effective at killing cancer cells while minimizing damage to healthy tissue. This article was authored by Shutao Gao, Yan Jin, Kuon Gu, and others.