 LCAT deficiency is a rare genetic disorder characterized by abnormal accumulation of lipids in various organs, including the kidneys. It can lead to progressive chronic kidney disease and eventually end-stage renal failure if left untreated. Symptoms include promnuria, dyslipidemia, and corneal opacities. Diagnosis is confirmed through a renal biopsy which reveals characteristic histopathologic changes. Treatment includes A.C.E. inhibitor and lipid-lowering medications, along with steroids. Gene replacement and recombinant LCAT replacement are also being studied with promising preliminary results. This article was authored by Muhammad Mahdi Altaf, Hadeel Almeina, Ahmed Abdel Fadiol, and others.