 Psoriasis is a chronic inflammatory skin disease with high global burden and its pathogenesis and treatment options have advanced significantly. However, less common forms of psoriasis remain elusive and severe adverse effects and disease recurrence should be addressed during treatment. This review provides an overview of the epidemiology, clinical subtypes, pathophysiology, comorbidities, signalling pathways, potential metabolic and epigenetic mechanisms, current treatments and disease recurrence in psoriasis. This article was authored by Jiogua, Hani Zhong, Wenrui Lin, and others.