 We have developed a strategy to design and evaluate high entropy alloys, HCA's, for structural use in the transportation and energy industries. Our goal properties include low, medium, and high use temperatures. To achieve our goals, we have created a systematic design approach using pallets of elements to meet target properties of each HCA family. Additionally, we have shown that intermetallic phases are consistent with HCA definitions. Furthermore, we have developed a three-step process to systematically screen and evaluate a vast number of HCA's by integrating high throughput computations and experiments. Finally, we have identified key components that are currently missing, such as materials libraries with microstructure gradients and high throughput tensile testing, which will help us further advance our understanding of HCA's. This article was authored by Daniel B. Miracle, Jonathan D. Miller, Oleg N. Senkov, and others.