 Welcome back to our meds smarter lecture series where we're taking a smarter approach to preparing future physician Before we get started if you'll take just a quick minute and click that like button and also Subscribe and turn the bell on so that you'll be notified when we post new videos We're gonna talk about four different types of E. Coli here now and these are your E I E C or intro invasive E. Coli the E T E C Which is intro toxogenic E. Coli the E P E C interopathogenic E. Coli and E H E C intro hemorrhagic E. Coli So let's look at these four different strains of E. Coli and see how they present differently based on their toxins So intro invasive E. Coli or E I E C this is Is Going to be where the microbe invades the intestinal mucosa causing necrosis and inflammation So think of E I the I and E I E C meaning it's invasive. It's invading that intestinal mucosa Causing dysentery and we often see the same type of symptoms that we talked about previously with Shigella If you need to re-review that you can pause this video go back to a previous Lecture that we have done here and look at the Shigella clinical manifestations Intro toxogenic E. Coli or E T E C this produces a heat label toxin that is heat stable It's an intro toxin so intro toxin intro toxogenic the T is important here No inflammation or invasion is associated with it But E T E C causes travelers diarrhea travelers diarrhea is a watery diarrhea That's pit typically all you see with intro toxogenic E. Coli Intro pathogenic or E P E C E. Coli Has no toxin produced to it. It basically will just adhere to surfaces It will flatten the villi and prevent absorption So if we're preventing absorption in the gut, what are we gonna see? Well, we're gonna see diarrhea most of time This isn't children So with E P E C the P you can think pediatrics of diarrhea in children Then finally intro hemorrhagic E. Coli. This is the one that you most often see discussed and thought about when you talk about E. Coli and GI infections 0157 H7 is the most common serotype of intro hemorrhagic E. Coli Coming from most commonly undercooked meats and then raw vegetables Shiga like toxin here can actually create hemolytic remick syndrome or H us Do you if you remember hemolytic remick syndrome has a triad to it? The triad is anemia thrombocytopenia and an acute kidney injury or aka I all that's gonna be due to the Microthrombi that forms around that damaged endothelium giving us mechanical hemolysis platelet consumption and then that decreased renal blood flow So what do we see with E H E C? Well, this is causing dysentery The toxin alone causes necrosis and inflammation to give us dysentery It doesn't ferment sorbitol where all the other E. Coli do ferment sorbitol So now we discussed we have E H E C. So the H we remember for hemorrhagic hamburgers because it's passed on an undercooked meat and then hemolytic remick syndrome that has that triad of anemia thrombocytopenia and acute kidney injury If you found this material helpful for your studying Please like and consider subscribing to the channel also share this video so that more people can benefit from it like you have