 Hydrogel-based bone tissue engineering is a promising approach for treating bone abnormalities and fractures. Hyaluronic acid, CHE, a natural polymer found throughout the human body, has been used to create hydrogels which mimic the natural extracellular matrix of bone tissue. These hydrogels are able to provide a suitable environment for cells to migrate and proliferate, as well as promote tissue regeneration. Additionally, HA-based hydrogels can be combined with other biomaterials and bioactive agents to enhance their mechanical strength and bioactivity. This combination of properties makes them ideal candidates for bone tissue engineering applications. This article was authored by He Sook Wong and Chung Sung Lee.