 The motivation behind my work comes from the fact that it's really difficult to predict how cancer drugs will work in a clinic by using quite simple models in the lab. It's very common to have some cancer cells and you just give them some drugs in a dish and that is not at all what we see in the body obviously. And so much energy goes into this and so much money goes into developing these drugs but using quite simple models of just cells in a dish. In the body there will be different regions of oxygen inside a tumour so there will be most likely an inner core which is dead already because it's got no oxygen at all. And surrounding that is an area of low oxygen where the cells actually become dormant and very drug resistant because we need oxygen for many of the drugs that we currently have available. So in my work we incorporate low oxygen into the cancer cells that I grow so that we can actually have an area that we know is drug resistant and we can combat that by targeting those cells so that we can better predict how these drugs will work and actually design drugs that will work on the currently drug resistant areas. So if that actually could be used then we could definitely improve the number of drugs that can work and we could decrease the amount of false positives that we get from using two simple models for cancer in the lab.