 Monoamine oxidase, MAO, inhibitors are medications used to treat various mental health conditions such as depression and anxiety. They work by blocking the action of monoamine oxidases, two enzymes that break down certain chemicals in the brain called monoamines. This prevents the breakdown of these chemicals, leading to increased levels of them in the body. These higher levels of monoamines can help improve symptoms of depression and anxiety. However, there are some side effects associated with MAO inhibitors, including a risk of hypertension due to the increase in monoamine levels. Additionally, some foods contain high amounts of tyramine and amino acid that can interact with MAO inhibitors and cause a dangerous rise in blood pressure. Therefore, it is important to be aware of what foods to avoid when taking this type of medication. This article was authored by John Paul Maurice-Fenberg and Jose Martin-Rabbi.