 Organonachip, OOC, technology has seen rapid advancements due to its potential applications in drug discovery and development. In this study, two OOC designs were compared and contrasted, focusing on their flow behavior and filling characteristics. The results showed that the elliptical chamber device offered superior flow and filling capabilities over the circular chamber device. Additionally, the biocompatibility and cell viability of both devices was confirmed through cell attachment and consistent cell growth. Overall, this study provides valuable insight into the design and performance of liveronachip prototypes, which can be used to further develop and optimize OOC technologies. This article was authored by Nerzana Bakuva, Sultan Ali Takhtarkan, Darkon Diaseminov, and others.