 At sea, Elegans neuromuscular junctions, two types of voltage-gated calcium channels, CAV2 and CAV1, are responsible for the release of distinct pools of synaptic vesicles. CAV2 channels are located in densely packed clusters near the active zone, while CAV1 channels are dispersed throughout the synapse. CAV2 channels are activated by voltage-gated calcium influx, which triggers the fusion of vesicles located within 33 nanometers of the dense projection. In contrast, CAV1 channels are activated by calcium influx from the ryanidine receptor, which is located nearby. This allows for the simultaneous activation of both channels, resulting in faster and more efficient neurotransmission. This article was authored by Brian D. Mueller, Sean A. Merrill, Shigeki Watanabe, and others.